Shah Anish M, Malhotra Ashish, Kothari Shivangi, Baddoura Walid, Depasquale Joseph, Spira Robert
Department of Internal Medicine, Saint Joseph's Regional Medical Center, Paterson, NJ, USA.
Hepatogastroenterology. 2011 Nov-Dec;58(112):2115-7. doi: 10.5754/hge09768.
Liver cirrhosis is generally considered irreversible but there are reports in which there is documented reversal of fibrosis/cirrhosis in various clinical conditions like Wilson's disease, hemochromatosis, primary biliary cirrhosis and autoimmune hepatitis. The subgroup of patients with autoimmune hepatitis that will have reversal of cirrhosis is not known. We present two cases with documented liver cirrhosis that had reversal of cirrhosis after treatment with immunosuppressive agents. We postulate that patients presenting with acute hepatitis and no other fibrogenic factors have higher chances of reversal of liver cirrhosis as compared to those presenting as chronic liver injury.
肝硬化通常被认为是不可逆的，但有报告称，在诸如威尔逊病、血色素沉着症、原发性胆汁性肝硬化和自身免疫性肝炎等各种临床病症中，纤维化/肝硬化有逆转的记录。自身免疫性肝炎患者中肝硬化会逆转的亚组尚不清楚。我们报告两例有记录的肝硬化病例，这两例患者在接受免疫抑制剂治疗后肝硬化出现了逆转。我们推测，与表现为慢性肝损伤的患者相比，表现为急性肝炎且无其他致纤维化因素的患者肝硬化逆转的可能性更高。
