Hu Xing-Rong, Cui Xian-Nian, Hu Qi-Tuo, Chen Jun
Xing-Rong Hu, Department of Imaging, The Central Hospital of Enshi Autonomous Prefecture, The Enshi Clinical College of Wuhan University, Enshi 445000, Hubei Province, China.
World J Gastroenterol. 2014 Jun 28;20(24):7964-70. doi: 10.3748/wjg.v20.i24.7964.
To compare apparent diffusion coefficient (ADC) values on diffusion-weighted imaging (DWI) of hepatic fibrosis patients with those of healthy controls and to identify their correlations with serum indices of liver fibrosis.
Hyaluronic acid (HA), laminin (LN), type III procollagen (PCIII), and collagen type IV (IV-C) were measured in 54 hepatic fibrosis patients and 23 normal controls, and ADC values were determined on DWI at different b values (b = 300, 500, 700 s/mm(2)). Correlations between serum indices and ADC values at different liver fibrosis stages were examined, and each index variation of liver fibrosis in different stages were compared, and correlation analysis of each index and the staging of liver fibrosis carried out, and the correlation of each index performed.
With progressive liver fibrosis, HA, PCIII, and IV-C levels increased (P < 0.01). As the b value increased, the ADC value decreased gradually with the hepatic fibrosis stages. In different groups with b values of 500 s/mm(2) and 700 s/mm(2), the ADC value decreased significantly as liver fibrosis progressed (P < 0.01). With b values of 500 s/mm(2) and 700 s/mm(2), there were negative correlations between ADC and LN, PCIII, HA, and IV-C. This pattern was observed only for HA and IV-C at a b value of 300 s/mm(2).
Serum indices of liver fibrosis and ADC values are useful for diagnosing liver fibrosis, with some correlations among them.
比较肝纤维化患者与健康对照者扩散加权成像（DWI）上的表观扩散系数（ADC）值，并确定其与肝纤维化血清指标的相关性。
测定54例肝纤维化患者和23例正常对照者的透明质酸（HA）、层粘连蛋白（LN）、Ⅲ型前胶原（PCIII）和Ⅳ型胶原（IV - C），并在不同b值（b = 300、500、700 s/mm²）的DWI上测定ADC值。检查不同肝纤维化阶段血清指标与ADC值之间的相关性，比较不同阶段肝纤维化各指标的变化，对各指标与肝纤维化分期进行相关性分析，并对各指标进行相关性分析。
随着肝纤维化进展，HA、PCIII和IV - C水平升高（P < 0.01）。随着b值增加，ADC值随肝纤维化阶段逐渐降低。在b值为500 s/mm²和700 s/mm²的不同组中，随着肝纤维化进展，ADC值显著降低（P < 0.01）。在b值为500 s/mm²和700 s/mm²时，ADC与LN、PCIII、HA和IV - C之间呈负相关。在b值为300 s/mm²时，仅观察到HA和IV - C呈现这种模式。
肝纤维化血清指标和ADC值对肝纤维化诊断有帮助，它们之间存在一定相关性。
