School of Chemistry and Chemical Engineering, Yangzhou University, Yangzhou, China.
Int J Biol Macromol. 2012 Mar 1;50(2):428-31. doi: 10.1016/j.ijbiomac.2011.12.027. Epub 2011 Dec 31.
Lauryl grafted sodium alginate (SA-C(12)) was prepared by the reaction between sodium alginate and dodecanol with 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide hydrochloride (EDC) as a coupling agent. The structure of SA-C(12) was confirmed by FT-IR, (1)H NMR, and thermoanalysis. Meantime, the degree of substitution (DS) of SA-C(12) was determined by GC. The reaction conditions were studied systematically, which included reaction time and temperature, the molar ratio of hexuronic acid in alginate to dodecanol (N(hexuronic)/N(dodecanol)) and N(hexuronic)/N(EDC), the mass of toluenesulfonic acid. By investigating the relationship between these conditions and DS, the optimal conditions with the maximum DS were obtained.
十二醇接枝海藻酸钠（SA-C(12)）通过 1-乙基-3-(3-二甲基氨基丙基)碳二亚胺盐酸盐（EDC）作为偶联剂与海藻酸钠和十二醇反应制得。通过傅里叶变换红外光谱（FT-IR）、（1）H 核磁共振和热分析确认了 SA-C(12)的结构。同时，通过气相色谱（GC）测定了 SA-C(12)的取代度（DS）。系统研究了反应条件，包括反应时间和温度、海藻酸钠中环己糖醛酸与十二醇的摩尔比（N(hexuronic)/N(dodecanol)）和 N(hexuronic)/N(EDC)以及对甲苯磺酸的质量。通过考察这些条件与 DS 的关系，得到了 DS 值最大的最佳条件。
