Senmaru Takafumi, Fukui Michiaki, Tanaka Muhei, Sakabe Kazumi, Ushigome Emi, Asano Mai, Yamazaki Masahiro, Hasegawa Goji, Nakamura Naoto
Department of Endocrinology and Metabolism, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, 465 Kajii-cho, Kawaramachi-Hirokoji, Kamigyo-ku, Kyoto, 602-8566, Japan.
Heart Vessels. 2013 Mar;28(2):151-6. doi: 10.1007/s00380-011-0227-0. Epub 2012 Jan 11.
N-terminal pro-brain natriuretic peptide (NT-proBNP), which is a useful biomarker of chronic heart failure, has been shown to be a strong predictor of cardiovascular mortality. The aim of this study was to evaluate the relationships between NT-proBNP and markers of subclinical atherosclerosis in patients with type 2 diabetes. Relationships of NT-proBNP to pulse wave velocity (PWV) or ankle-brachial index (ABI) as well as to various parameters, including body mass index, blood pressure, serum lipid concentration, serum uric acid concentration, and glycemic control (hemoglobin A1c), age, hemoglobin, serum creatinine concentration, severity of diabetic nephropathy or retinopathy, current treatment of diabetes, cardiothoracic ratio on chest radiograph, presence of left ventricular hypertrophy and/or ST-T changes evaluated by electrocardiograph, smoking status and presence of cardiovascular disease were investigated in 323 consecutive patients with type 2 diabetes. Log (NT-proBNP) correlated positively with PWV (r = 0.283, p < 0.0001) and correlated negatively with ABI (r = -0.144, p = 0.0094). Multiple regression analysis demonstrated that age (β = 0.200, p = 0.0033), systolic blood pressure (β = 0.246, p < 0.0001), total cholesterol (β = -0.135, p = 0.0326), uric acid (β = 0.133, p = 0.0462), creatinine (β = -0.184, p = 0.0122), smoking status (β = -0.129, p = 0.0499) and log (NT-proBNP) (β = 0.177, p = 0.0149) were independently correlated with PWV and that systolic blood pressure (β = -0.145, p = 0.0310), log triglyceride (β = -0.151, p = 0.0397) and log (NT-proBNP) (β = -0.207, p = 0.0094) were independently correlated with ABI. In conclusion, NT-proBNP could be a marker of subclinical atherosclerosis in patients with type 2 diabetes.
N 末端脑钠肽前体（NT-proBNP）是慢性心力衰竭的一种有用生物标志物，已被证明是心血管死亡率的有力预测指标。本研究的目的是评估 2 型糖尿病患者中 NT-proBNP 与亚临床动脉粥样硬化标志物之间的关系。在 323 例连续的 2 型糖尿病患者中，研究了 NT-proBNP 与脉搏波速度（PWV）或踝臂指数（ABI）的关系，以及与各种参数的关系，这些参数包括体重指数、血压、血脂浓度、血清尿酸浓度、血糖控制（糖化血红蛋白）、年龄、血红蛋白、血清肌酐浓度、糖尿病肾病或视网膜病变的严重程度、当前糖尿病治疗情况、胸部 X 光片上的心胸比率、通过心电图评估的左心室肥厚和/或 ST-T 改变的存在情况、吸烟状况以及心血管疾病的存在情况。Log（NT-proBNP）与 PWV 呈正相关（r = 0.283，p < 0.0001），与 ABI 呈负相关（r = -0.144，p = 0.0094）。多元回归分析表明，年龄（β = 0.200，p = 0.0033）、收缩压（β = 0.246，p < 0.0001）、总胆固醇（β = -0.135，p = 0.0326）、尿酸（β = 0.133，p = 0.0462）、肌酐（β = -0.184，p = 0.0122）、吸烟状况（β = -0.129，p = 0.0499）和 Log（NT-proBNP）（β = 0.177，p = 0.0149）与 PWV 独立相关，收缩压（β = -0.145，p = 0.0310）、Log 甘油三酯（β = -0.151，p = 0.0397）和 Log（NT-proBNP）（β = -0.207，p = 0.0094）与 ABI 独立相关。总之，NT-proBNP 可能是 2 型糖尿病患者亚临床动脉粥样硬化的一个标志物。
