银屑病患者颈动脉平均内膜中层厚度与脑钠肽的相关性
Correlation between Carotid Artery Mean Intima-Media Thickness and brain Natriuretic Peptide in Patients with Psoriasis.
作者信息
Niknezhad Nasim, Shahidi-Dadras Mohammad, Rajabi Fateme, Khah Hamidreza Haghighat, Niknejad Nakisa, Younespour Shima
机构信息
Skin Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Network of Dermatology Research (NDR), Universal Scientific Education and Research Network (USERN), Tehran, Iran.
出版信息
J Psoriasis Psoriatic Arthritis. 2022 Oct;7(4):187-191. doi: 10.1177/24755303221118037. Epub 2022 Aug 8.
BACKGROUND
Numerous studies have documented an association between psoriasis and subclinical atherosclerosis.
OBJECTIVE
We aimed to investigate the effects of psoriasis on the levels of N-terminal prohormone B type natriuretic peptide (NT-proBNP) and clarify whether this factor correlates with the evaluations of subclinical atherosclerosis, measured with mean intima-media thickness (MIMT) of the carotid artery.
METHODS
Sixty-one psoriatic patients and sixty-one healthy, age and sex-matched volunteers were enrolled. MIMT was assessed via ultrasonography and serum NT-proBNP level were measured by electrochemiluminescence.
RESULTS
Both NT-proBNP and MIMT were significantly higher in psoriasis patients. This remained true even after controlling for the effects of age and gender. MIMT was positively correlated with age and serum NT-proBNP level in both groups.
CONCLUSIONS
In conclusion, NT-proBNP levels may be used as a predictor of subclinical atherosclerosis in patients with psoriasis.
背景
大量研究记录了银屑病与亚临床动脉粥样硬化之间的关联。
目的
我们旨在研究银屑病对N端前体B型利钠肽（NT-proBNP）水平的影响，并阐明该因子是否与通过颈动脉平均内膜中层厚度（MIMT）测量的亚临床动脉粥样硬化评估相关。
方法
招募了61例银屑病患者和61例年龄、性别匹配的健康志愿者。通过超声检查评估MIMT，采用电化学发光法测量血清NT-proBNP水平。
结果
银屑病患者的NT-proBNP和MIMT均显著更高。即使在控制年龄和性别的影响后，情况依然如此。两组中MIMT均与年龄和血清NT-proBNP水平呈正相关。
结论
总之，NT-proBNP水平可作为银屑病患者亚临床动脉粥样硬化的预测指标。
Zotero 插件