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本文引用的文献

1
Can serum level of N-terminal pro B-type natriuretic peptide be used in patients with psoriasis as a predictor of cardiovascular disease?血清 N 端脑利钠肽前体水平能否用于预测银屑病患者的心血管疾病？
Dermatol Ther. 2019 May;32(3):e12865. doi: 10.1111/dth.12865. Epub 2019 Mar 28.
2
Increased risk of arrhythmia in patients with psoriatic disease: A nationwide population-based matched cohort study.银屑病患者心律失常风险增加：一项全国范围内基于人群的匹配队列研究。
J Am Acad Dermatol. 2015 Sep;73(3):429-38. doi: 10.1016/j.jaad.2015.06.023. Epub 2015 Jul 15.
3
Increased serum leptin and resistin levels and increased carotid intima-media wall thickness in patients with psoriasis: is psoriasis associated with atherosclerosis?银屑病患者血清瘦素和抵抗素水平升高及颈动脉内膜中层厚度增加：银屑病与动脉粥样硬化有关吗？
J Am Acad Dermatol. 2014 Oct;71(4):642-8. doi: 10.1016/j.jaad.2014.06.006. Epub 2014 Jul 16.
4
Impaired left ventricular apical rotation is associated with disease activity of psoriatic arthritis.左心室心尖旋转受损与银屑病关节炎的疾病活动相关。
J Rheumatol. 2014 Apr;41(4):706-13. doi: 10.3899/jrheum.130589. Epub 2014 Mar 1.
5
Is left ventricular diastolic dysfunction independent from presence of hypertension in metabolic syndrome? An echocardiographic study.代谢综合征中左心室舒张功能障碍是否独立于高血压存在？一项超声心动图研究。
J Cardiol. 2014 Sep;64(3):194-8. doi: 10.1016/j.jjcc.2014.01.002. Epub 2014 Feb 10.
6
Increase in ventricular-arterial stiffness in patients with psoriatic arthritis.银屑病关节炎患者的心室-动脉僵硬度增加。
Rheumatology (Oxford). 2012 Dec;51(12):2215-23. doi: 10.1093/rheumatology/kes213. Epub 2012 Aug 25.
7
N-terminal pro-brain natriuretic peptide could be a marker of subclinical atherosclerosis in patients with type 2 diabetes.N端前脑钠肽可能是2型糖尿病患者亚临床动脉粥样硬化的一个标志物。
Heart Vessels. 2013 Mar;28(2):151-6. doi: 10.1007/s00380-011-0227-0. Epub 2012 Jan 11.
8
NT-proBNP levels, atherosclerosis and vascular function in asymptomatic type 2 diabetic patients with microalbuminuria: peripheral reactive hyperaemia index but not NT-proBNP is an independent predictor of coronary atherosclerosis.在伴有微量白蛋白尿的无症状 2 型糖尿病患者中，NT-proBNP 水平、动脉粥样硬化和血管功能：外周反应性充血指数而非 NT-proBNP 是冠状动脉粥样硬化的独立预测因子。
Cardiovasc Diabetol. 2011 Aug 3;10:71. doi: 10.1186/1475-2840-10-71.
9
High prevalence of subclinical left ventricular dysfunction in patients with psoriatic arthritis.银屑病关节炎患者存在亚临床左心室功能障碍的高患病率。
J Rheumatol. 2011 Jul;38(7):1363-70. doi: 10.3899/jrheum.101136. Epub 2011 Apr 1.
10
Subclinical atherosclerosis in patients with chronic psoriasis: a potential association.慢性银屑病患者的亚临床动脉粥样硬化：潜在关联。
J Eur Acad Dermatol Venereol. 2010 Jun;24(6):661-6. doi: 10.1111/j.1468-3083.2009.03481.x. Epub 2009 Nov 2.

银屑病患者颈动脉平均内膜中层厚度与脑钠肽的相关性

Correlation between Carotid Artery Mean Intima-Media Thickness and brain Natriuretic Peptide in Patients with Psoriasis.

作者信息

Niknezhad Nasim, Shahidi-Dadras Mohammad, Rajabi Fateme, Khah Hamidreza Haghighat, Niknejad Nakisa, Younespour Shima

机构信息

Skin Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Network of Dermatology Research (NDR), Universal Scientific Education and Research Network (USERN), Tehran, Iran.

出版信息

J Psoriasis Psoriatic Arthritis. 2022 Oct;7(4):187-191. doi: 10.1177/24755303221118037. Epub 2022 Aug 8.

DOI:10.1177/24755303221118037
PMID:39296963
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11361502/
Abstract

BACKGROUND

Numerous studies have documented an association between psoriasis and subclinical atherosclerosis.

OBJECTIVE

We aimed to investigate the effects of psoriasis on the levels of N-terminal prohormone B type natriuretic peptide (NT-proBNP) and clarify whether this factor correlates with the evaluations of subclinical atherosclerosis, measured with mean intima-media thickness (MIMT) of the carotid artery.

METHODS

Sixty-one psoriatic patients and sixty-one healthy, age and sex-matched volunteers were enrolled. MIMT was assessed via ultrasonography and serum NT-proBNP level were measured by electrochemiluminescence.

RESULTS

Both NT-proBNP and MIMT were significantly higher in psoriasis patients. This remained true even after controlling for the effects of age and gender. MIMT was positively correlated with age and serum NT-proBNP level in both groups.

CONCLUSIONS

In conclusion, NT-proBNP levels may be used as a predictor of subclinical atherosclerosis in patients with psoriasis.

摘要

背景

大量研究记录了银屑病与亚临床动脉粥样硬化之间的关联。

目的

我们旨在研究银屑病对N端前体B型利钠肽（NT-proBNP）水平的影响，并阐明该因子是否与通过颈动脉平均内膜中层厚度（MIMT）测量的亚临床动脉粥样硬化评估相关。

方法

招募了61例银屑病患者和61例年龄、性别匹配的健康志愿者。通过超声检查评估MIMT，采用电化学发光法测量血清NT-proBNP水平。

结果

银屑病患者的NT-proBNP和MIMT均显著更高。即使在控制年龄和性别的影响后，情况依然如此。两组中MIMT均与年龄和血清NT-proBNP水平呈正相关。

结论

总之，NT-proBNP水平可作为银屑病患者亚临床动脉粥样硬化的预测指标。