Qazi Basit Saleem, Tang Kai, Qazi Asma
Department of Orthopedic Surgery Spine Unit, First Affiliated Hospital of Dalian Medical University, 222 Zhongshan Road, Dalian, Liaoning 116011, China.
Int J Inflam. 2011;2011:908468. doi: 10.4061/2011/908468. Epub 2011 Dec 22.
Interleukin-8 has long been recognized to have anti-inflammatory activity, which has been established in various models of infection, inflammation, and cancer. Several cell types express the receptor for the cytokine IL-8 and upon its recognition produce molecules that are active both locally and systemically. Many different types of cells, in particular monocytes, neutrophils, epithelial, fibroblast, endothelial, mesothelial, and tumor cells, secrete IL-8. Increased expression of IL-8 and/or its receptors has been characterized in many chronic inflammatory conditions, including psoriasis, ARDS, COPD, and RA as well as many cancers, and its upregulation often correlates with disease activity. IL-8 constitutes the CXC class of chemokines, a potent chemoattractant and activator of neutrophils and other immune cells. It is a proangiogenic cytokine that is overexpressed in many human cancers. Therefore, inhibiting the effects of IL-8 signaling may be a significant therapeutic intervention.
白细胞介素-8长期以来被认为具有抗炎活性，这已在各种感染、炎症和癌症模型中得到证实。几种细胞类型表达细胞因子IL-8的受体，在识别该受体后会产生在局部和全身均具有活性的分子。许多不同类型的细胞，特别是单核细胞、中性粒细胞、上皮细胞、成纤维细胞、内皮细胞、间皮细胞和肿瘤细胞，都会分泌IL-8。在许多慢性炎症性疾病中，包括银屑病、急性呼吸窘迫综合征（ARDS）、慢性阻塞性肺疾病（COPD）和类风湿性关节炎（RA）以及许多癌症中，IL-8及其受体的表达均有所增加，其上调通常与疾病活动相关。IL-8属于CXC类趋化因子，是一种强大的中性粒细胞和其他免疫细胞的化学引诱剂和激活剂。它是一种促血管生成细胞因子，在许多人类癌症中过度表达。因此，抑制IL-8信号传导的作用可能是一种重要的治疗干预措施。
