Szaflarski Witold, Nowicki Michał, Zabel Maciej
Katedra i Zakład Histologii i Embriologii, Uniwersytet Medyczny im. K. Marcinkowskiego w Poznaniu, Poznań.
Postepy Biochem. 2011;57(3):266-73.
The cellular vaults have been described for the first time in 1986 as ribonucleoprotein complexes composed of three proteins, MVP, TEP1 and vPARP and several vRNA strains. Biochemical and structural studies revealed their ubiquitous existence in the cytoplasm of many eukaryotic cells and their barrel-like structure indicating their engagement in the intracellular transport. Furthermore, the high homology between MVP and LRP which was already known to be involved in multidrug resistance mechanism opened a discussion about the role of vaults in both normal and cancer cells. The histopathology research demonstrated an increased amount of MVP/LRP proteins in the cancer as well as showed translocation possibility between cytoplasm and nuclear envelope, which can be of crucial point in the prevention of nucleus against anticancer drugs.
细胞穹窿最早于1986年被描述为一种核糖核蛋白复合物，由三种蛋白质（MVP、TEP1和vPARP）以及几种vRNA菌株组成。生化和结构研究表明，它们普遍存在于许多真核细胞的细胞质中，其桶状结构表明它们参与细胞内运输。此外，已知参与多药耐药机制的MVP和LRP之间的高度同源性引发了关于穹窿在正常细胞和癌细胞中作用的讨论。组织病理学研究表明，癌症中MVP/LRP蛋白的含量增加，并且显示出在细胞质和核膜之间易位的可能性，这可能是细胞核抵御抗癌药物的关键点。
