脑脊液的免疫组织化学分析用于癌性和淋巴瘤性柔脑膜炎症。
Immunohistochemical analysis of the cerebrospinal fluid for carcinomatous and lymphomatous leptomeningitis.
作者信息
Hovestadt A, Henzen-Logmans S C, Vecht C J
机构信息
Department of Neurology, Dr. Daniel Den Hoed Cancer Centre, Rotterdam, The Netherlands.
出版信息
Br J Cancer. 1990 Oct;62(4):653-4. doi: 10.1038/bjc.1990.349.
Abstract
To evaluate the sensitivity and specificity of immunohistochemical analysis in relation to the standard cytological examination of the cerebrospinal fluid (CSF) in patients with either a solid tumour or a haematological malignancy and possible leptomeningeal disease, 68 CSF-samples derived from 68 patients were examined. The sensitivity of immunohistochemical analysis was 0.54 and its specificity 0.98. Only one patient had a positive immunohistochemistry and a negative cytology. The gain of adding immunohistochemistry to cytology is nearly 8%. It is concluded that immunohistochemistry should not be used as a screening test for leptomeningeal disease in patients with cancer.
摘要
为评估免疫组化分析相对于实体瘤或血液系统恶性肿瘤且可能存在软脑膜疾病患者脑脊液（CSF）标准细胞学检查的敏感性和特异性，对68例患者的68份CSF样本进行了检测。免疫组化分析的敏感性为0.54，特异性为0.98。仅有1例患者免疫组化呈阳性而细胞学检查呈阴性。在细胞学检查基础上增加免疫组化检查的获益率近8%。得出结论，免疫组化不应作为癌症患者软脑膜疾病的筛查试验。
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