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亮氨酸补充剂结合抗阻运动可改善地塞米松处理大鼠的血浆脂质谱。

Leucine supplementation combined with resistance exercise improves the plasma lipid profile of dexamethasone-treated rats.

机构信息

Laboratory of Applied Nutrition and Metabolism, Physical Education and Sports School, University of São Paulo - São Paulo, SP, Brazil.

出版信息

Lipids Health Dis. 2012 Jan 11;11:7. doi: 10.1186/1476-511X-11-7.

DOI:10.1186/1476-511X-11-7
PMID:22236609
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3268083/
Abstract

The impact of leucine supplementation and resistance exercise (RE) on plasma lipid profile was evaluated in adult rats treated with dexamethasone, an experimental model of dyslipidemia. Total cholesterol did not differ among groups. Furthermore, leucine supplementation did not promote improvement in the plasma total cholesterol and LDL-c of the animals. However, plasma TG and VLDL-c were significantly decreased and HDL-c increased after 7 days of leucine supplementation combined with RE. In conclusion, leucine supplementation combined with RE, but not isolated, improved the plasma lipid profile of dexamethasone-induced dyslipidemic rats.

摘要

在接受地塞米松治疗的成年大鼠（一种脂代谢紊乱的实验模型）中，评估了亮氨酸补充和抗阻运动（RE）对血浆脂质谱的影响。各组间总胆固醇无差异。此外，亮氨酸补充并没有促进动物血浆总胆固醇和 LDL-c 的改善。然而，亮氨酸补充联合 RE 治疗 7 天后，可显著降低血浆 TG 和 VLDL-c，升高 HDL-c。总之，亮氨酸补充联合 RE 治疗可改善地塞米松诱导的脂代谢紊乱大鼠的血浆脂质谱，但单纯补充亮氨酸则无效。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2d78/3268083/275a6d41940b/1476-511X-11-7-1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2d78/3268083/275a6d41940b/1476-511X-11-7-1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2d78/3268083/275a6d41940b/1476-511X-11-7-1.jpg

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2
Leucine supplementation improves adiponectin and total cholesterol concentrations despite the lack of changes in adiposity or glucose homeostasis in rats previously exposed to a high-fat diet.尽管先前暴露于高脂肪饮食的大鼠的肥胖或葡萄糖稳态没有变化，但亮氨酸补充可改善脂联素和总胆固醇浓度。
Nutr Metab (Lond). 2011 Sep 7;8(1):62. doi: 10.1186/1743-7075-8-62.
3
Effects of creatine supplementation on muscle wasting and glucose homeostasis in rats treated with dexamethasone.
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Amino Acids. 2012 May;42(5):1695-701. doi: 10.1007/s00726-011-0871-9. Epub 2011 Mar 5.
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An overview of the therapeutic effects of leucine supplementation on skeletal muscle under atrophic conditions.亮氨酸补充对萎缩状态下骨骼肌的治疗效果概述。
Amino Acids. 2011 Feb;40(2):287-300. doi: 10.1007/s00726-010-0636-x. Epub 2010 Jun 1.
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