叶酸代谢基因 MTR、MTRR 和 CBS 多态性与乳腺癌风险。
Polymorphisms in the folate-metabolizing genes MTR, MTRR, and CBS and breast cancer risk.
机构信息
Institute of Chemical Biology and Fundamental Medicine, Group of Pharmacogenomics, Novosibirsk, Russia.
出版信息
Cancer Epidemiol. 2012 Apr;36(2):e95-e100. doi: 10.1016/j.canep.2011.11.010. Epub 2012 Jan 10.
Alterations in the nucleotide sequences of folate-metabolizing genes can increase the risk of malignant transformation. The aim of our study was to investigate the association of three single-nucleotide polymorphisms (SNPs) in the folate-metabolizing genes - A2756G MTR, A66G MTRR, and 844ins68 CBS - which have putative functional significance in breast cancer risk. The allele and genotype frequencies of the SNPs were determined in a case group (840 women with sporadic breast cancer) and a control group (770 women). No statistically significant association of studied SNPs with breast cancer was revealed. A meta-analysis, which included data obtained from the literature and the present research, did not reveal any statistically significant associations of these SNPs with breast cancer. The results obtained provide evidence that these SNPs are not involved in the development of breast cancer.
叶酸代谢基因核苷酸序列的改变会增加恶性转化的风险。我们的研究目的是探讨叶酸代谢基因中三个单核苷酸多态性（SNP）（MTR 的 A2756G、MTRR 的 A66G 和 CBS 的 844ins68）与乳腺癌风险之间的关联，这些 SNP 具有潜在的功能意义。在病例组（840 名散发性乳腺癌女性）和对照组（770 名女性）中确定了 SNP 的等位基因和基因型频率。研究发现，这些 SNP 与乳腺癌之间没有统计学意义的关联。荟萃分析包括从文献和本研究中获得的数据，也没有发现这些 SNP 与乳腺癌有任何统计学意义的关联。研究结果表明，这些 SNP 不参与乳腺癌的发生。
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