Breast Cancer Res. 2012 Jan 9;14(1):101. doi: 10.1186/bcr3056.
Septins comprise a conserved family of GTPase proteins. Of these, human SEPT9 has been widely implicated in cancers of epithelial origin, including breast cancer, as well as leukemia. In a previous issue of Breast Cancer Research, Connolly and colleagues present compelling data further supporting a role for SEPT9 isoforms in early breast cancer development as well as evidence suggesting that cellular localization patterns of SEPT9 isoforms may contribute to oncogenesis.
Septins 是一组保守的 GTPase 蛋白家族。其中，人类 SEPT9 广泛参与上皮来源的癌症，包括乳腺癌和白血病。在之前的一期《乳腺癌研究》中，Connolly 及其同事提供了令人信服的证据，进一步支持 SEPT9 异构体在早期乳腺癌发展中的作用，并表明 SEPT9 异构体的细胞定位模式可能有助于肿瘤发生。
