用于吡嗪选择性功能化的新型锂锌酸盐方法：直接双脱质子化与亲核烷基化。
New lithium-zincate approaches for the selective functionalisation of pyrazine: direct dideprotozincation vs. nucleophilic alkylation.
机构信息
WestCHEM, Department of Pure and Applied Chemistry, University of Strathclyde, Glasgow, G1 1XL, UK.
出版信息
Chem Commun (Camb). 2012 Feb 14;48(14):1985-7. doi: 10.1039/c2cc16959b. Epub 2012 Jan 11.
PMID:22237409
Abstract
Comparing the reactivity of the related lithium zincates [(THF)LiZn(TMP)(t)Bu(2)] (1) and [(PMDETA)LiZn(t)Bu(3)] (2) towards pyrazine discloses two new bimetallic approaches for the selective 2,5-dideprotonation and room temperature C-H alkylation of this sensitive heterocycle.
摘要
比较相关的锂锌酸盐[(THF)LiZn(TMP)(t)Bu(2)]（1）和[(PMDETA)LiZn(t)Bu(3)]（2）与吡嗪的反应性，揭示了两种新的双金属方法，可用于选择性地对这种敏感杂环进行 2,5-二去质子化和室温 C-H 烷基化。
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