WestCHEM, Department of Pure and Applied Chemistry, University of Strathclyde, Glasgow, G1 1XL, UK.
Angew Chem Int Ed Engl. 2016 Oct 10;55(42):13147-13150. doi: 10.1002/anie.201607284.
This study establishes a new trans-metal-trapping (TMT) procedure based on a mixture of LiTMP (the base) and tris(trimethylsilylmethyl)gallium [Ga(CH SiMe ) , GaR ] (the trap) that, operating in a tandem manner, is effective for the regioselective deprotonation of sensitive diazines in hydrocarbon solution, as illustrated through reactions of pyrazine, pyridazine, and pyrimidine, as well as through the N-S heterocycle benzothiazole. The metallo-activated complexes of all of these compounds were isolated and structurally defined.
本研究建立了一种基于 LiTMP（碱）和三（三甲基甲硅烷基）甲基镓[Ga(CH SiMe ) ，GaR]（捕获剂）混合物的新型跨金属捕获（TMT）程序，该程序以串联方式操作，可有效实现烃溶液中敏感二嗪的区域选择性去质子化，如通过吡嗪、哒嗪和嘧啶以及 N-S 杂环苯并噻唑的反应所示。这些化合物的所有金属活化配合物均被分离并进行了结构定义。
