Neuroscience Research Unit, Puerta de Hierro-Majadahonda Hospital, Madrid, Spain.
Histol Histopathol. 2012 Mar;27(3):303-15. doi: 10.14670/HH-27.303.
Currently, it is accepted that brain injury promotes endogenous neurogenesis in mammals, primarily in the subventricular zone (SVZ), and newborn cells can migrate to the injured area. We examined the pattern of endogenous neurogenesis in adult rats after intracerebral hemorrhage (ICH) that was caused by intrastrial administration of collagenase type IV. Our results showed that ICH induced strong endogenous neurogenesis between 72 hours and 7 days after injury, but that the majority of newborn cells did not survive longer than 3 weeks due to apoptosis-mediated cell death. Furthermore, endogenous neurogenesis remained into a small extent at least 1 year after ICH. Because of the growing interest in new strategies for brain regeneration, these data suggest endogenous neurogenesis and inhibiting apoptosis of newborn neuroblasts as potential strategies to improve the consequences of hemorrhagic stroke in humans.
目前，人们普遍认为脑损伤会促进哺乳动物内源性神经发生，主要发生在侧脑室下区（SVZ），新生细胞可以迁移到损伤区域。我们研究了胶原酶 IV 诱导的脑室内注射引起的脑出血（ICH）后成年大鼠内源性神经发生的模式。我们的结果表明，ICH 诱导了损伤后 72 小时至 7 天之间强烈的内源性神经发生，但由于凋亡介导的细胞死亡，大多数新生细胞不会存活超过 3 周。此外，ICH 后至少 1 年内，内源性神经发生仍在一定程度上存在。由于人们对大脑再生的新策略越来越感兴趣，这些数据表明内源性神经发生和抑制新生神经母细胞的凋亡可能是改善人类出血性中风后果的潜在策略。
