Department of Clinical Medicine, Trinity College Dublin, Adelaide & Meath Hospital, Dublin, Ireland.
Int J Vitam Nutr Res. 2011 Jul;81(4):205-10. doi: 10.1024/0300-9831/a000066.
There is growing evidence that vitamin D may have immunomodulatory properties in Crohn's disease (CD). The aim of this study was to determine if serum 25-hydroxy-vitamin D [25(OH)D] was associated with inflammatory cytokines, IL-10, and TNF-alpha levels in patients with inactive CD.
This was a prospective study of 75 adults with quiescent CD. Serum 25(OH)D was measured by radioimmunoassay and serum IL-10 and TNF-alpha by ELISA. Disease activity was assessed by the Crohn's disease activity index (CDAI) and C-reactive protein (CRP).
IL-10 levels were significantly lower in patients with vitamin D insufficiency compared with the vitamin D replete group (mean and SE 2.48 ± 0.51 v 6.77 ± 2.49 pg/mL, p < 0.001). There were, however, no differences in serum TNF-alpha or CRP levels based on vitamin D status. The use of a vitamin D supplement at a low dose (200 IU) did not significantly influence IL-10 levels.
Circulating levels of IL-10, but not TNF-alpha, were significantly lower in CD patients with inadequate serum 25(OH)D. This suggests that poor vitamin D status may be linked to reduced anti-inflammatory capacity in this group.
越来越多的证据表明维生素 D 可能对克罗恩病（CD）具有免疫调节作用。本研究旨在确定血清 25-羟维生素 D [25(OH)D] 是否与处于缓解期的 CD 患者的炎症细胞因子、IL-10 和 TNF-α水平相关。
这是一项对 75 名处于缓解期的 CD 成人患者进行的前瞻性研究。采用放射免疫法测定血清 25(OH)D，采用 ELISA 法测定血清 IL-10 和 TNF-α。通过克罗恩病活动指数（CDAI）和 C 反应蛋白（CRP）评估疾病活动度。
与维生素 D 充足组相比，维生素 D 不足的患者 IL-10 水平显著降低（均值和 SE 分别为 2.48 ± 0.51 和 6.77 ± 2.49 pg/mL，p < 0.001）。但是，根据维生素 D 状态，血清 TNF-α或 CRP 水平没有差异。低剂量（200 IU）使用维生素 D 补充剂并没有显著影响 IL-10 水平。
血清 25(OH)D 不足的 CD 患者的循环 IL-10 水平，而不是 TNF-α水平，显著降低。这表明在该组中，维生素 D 状态不佳可能与抗炎能力降低有关。
