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患有钩端螺旋体相关性葡萄膜炎的马的眼房水和血清中针对一种新型钩端螺旋体蛋白LruC的抗体。

Antibodies to a novel leptospiral protein, LruC, in the eye fluids and sera of horses with Leptospira-associated uveitis.

作者信息

Verma Ashutosh, Matsunaga James, Artiushin Sergey, Pinne Marija, Houwers Dirk J, Haake David A, Stevenson Brian, Timoney John F

机构信息

M. H. Gluck Equine Research Center, Department of Veterinary Science, University of Kentucky, Lexington, Kentucky, USA.

出版信息

Clin Vaccine Immunol. 2012 Mar;19(3):452-6. doi: 10.1128/CVI.05524-11. Epub 2012 Jan 11.

DOI:10.1128/CVI.05524-11
PMID:22237897
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3294619/
Abstract

Screening of an expression library of Leptospira interrogans with eye fluids from uveitic horses resulted in identification of a novel protein, LruC. LruC is located in the inner leaflet of the leptospiral outer membrane, and an lruC gene was detected in all tested pathogenic L. interrogans strains. LruC-specific antibody levels were significantly higher in eye fluids and sera of uveitic horses than healthy horses. These findings suggest that LruC may play a role in equine leptospiral uveitis.

摘要

用葡萄膜炎马的眼液筛选问号钩端螺旋体表达文库，鉴定出一种新型蛋白LruC。LruC位于钩端螺旋体外膜的内小叶，在所有测试的问号钩端螺旋体致病菌株中均检测到lruC基因。葡萄膜炎马的眼液和血清中LruC特异性抗体水平显著高于健康马。这些发现表明LruC可能在马钩端螺旋体葡萄膜炎中起作用。

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本文引用的文献

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Cross-reactivity of antibodies against leptospiral recurrent uveitis-associated proteins A and B (LruA and LruB) with eye proteins.抗钩端螺旋体复发性葡萄膜炎相关蛋白 A 和 B（LruA 和 LruB）与眼内蛋白的交叉反应性。
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