用于水溶液中 D-半胱氨酸对映选择性检测的比率荧光探针。
Ratiometric fluorescent probe for enantioselective detection of D-cysteine in aqueous solution.
机构信息
Department of Chemistry, Hong Kong Baptist University, Kowloon Tong, Hong Kong SAR, China.
出版信息
Beilstein J Org Chem. 2011;7:1508-15. doi: 10.3762/bjoc.7.176. Epub 2011 Nov 9.
Abstract
A ratiometric fluorescent probe based on a Cd(2+)-ACAQ complex was designed and demonstrated for the chemo- and enantioselective detection of cysteine in 99:1 buffered HEPES:ACN solutions. Under the measuring conditions, the sensor demonstrates high selectivity toward Cys against Hcy and GSH, and an enantioselectivity of 3.35 can be achieved for antipodal forms of Cys.
摘要
基于 Cd(2+)-ACAQ 配合物的比率荧光探针被设计并证明可用于在 99:1 的缓冲 HEPES:ACN 溶液中对半胱氨酸进行化学和对映选择性检测。在测量条件下，该传感器对 Cys 相对于 Hcy 和 GSH 表现出高选择性，并且可以实现对映体形式的 Cys 的 3.35 的对映选择性。
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