设计并合成一种对巯基具有高选择性的荧光开启型探针，用于活细胞中的硫醇生物成像。
Design and synthesis of a highly selective fluorescent turn-on probe for thiol bioimaging in living cells.
机构信息
ZJU-ENS Joint Laboratory of Medicinal Chemistry, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China.
出版信息
Org Biomol Chem. 2010 Aug 21;8(16):3627-30. doi: 10.1039/c004344c. Epub 2010 Jun 30.
DOI:10.1039/c004344c
PMID:20593078
Abstract
A new fluorescent turn-on probe for the rapid optical sensing of thiols has been designed and synthesized. The probe displays high on/off signal ratios and high selectivity towards thiols. The potential of the probe as a biosensor for thiols was demonstrated by imaging of thiols in living cells.
摘要
一种新的用于快速光学检测巯基的荧光开启探针已经被设计和合成。该探针具有高的开/关信号比值和对巯基的高选择性。该探针作为一种检测巯基的生物传感器的潜力通过在活细胞中对巯基的成像得到了证明。
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