Department of Chemistry, University of Victoria, Victoria BC, Canada.
Beilstein J Org Chem. 2011;7:1562-9. doi: 10.3762/bjoc.7.184. Epub 2011 Nov 22.
Voltage-clamp experiments of eight oligoester bolaamphiphiles in two subclasses are described. Syntheses of three new terephthalate-based compounds were achieved in three linear steps. Together with five previously described, related compounds, the ion transport activity was assessed by means of the voltage-clamp technique. All of the compounds show multiple types of conductance behavior in planar bilayers, a subset of which was exponentially voltage-dependent. The varied and irregular activities were summarized with the aid of a recently developed "activity-grid" method.
描述了两个子类中的 8 种低聚酯 bolaamphiphiles 的电压钳实验。通过三个线性步骤实现了三种新的对苯二甲酸盐基化合物的合成。与之前描述的五种相关化合物一起，通过电压钳技术评估了离子传输活性。所有化合物在平面双层中均表现出多种电导行为，其中一部分呈指数电压依赖性。通过最近开发的“活性网格”方法对变化和不规则的活性进行了总结。
