Sotaniemi Kyösti
Oulun yliopisto, neurologian klinikka.
Duodecim. 2011;127(22):2409-14.
Botulin is established as first-line treatment in cervical dystonia, blepharospasm, hemifacial spasm and stroke-related spasticity of the distal parts of the upper limb. In addition, many other motor disorders and muscular hyperactivity states and neurologic symptoms and manifestations, in which temporary muscle paralysis, analgesic properties and effects on the functioning of the autonomic nervous system brought about by botulin can be utilized, have become indications for use. With proper dosage, botulin has proven to be safe even in prolonged use, the effect usually lasting for years.
肉毒杆菌素已被确立为治疗颈部肌张力障碍、眼睑痉挛、半面痉挛以及上肢远端与中风相关的痉挛的一线疗法。此外，许多其他运动障碍、肌肉活动亢进状态以及神经症状和表现，鉴于肉毒杆菌素可带来暂时的肌肉麻痹、止痛特性以及对自主神经系统功能的影响，已成为其适用症。使用适当剂量时，肉毒杆菌素即便长期使用也已证明是安全的，其效果通常可持续数年。
