Halman M, Goldbloom D S
Department of Psychiatry, Toronto General Hospital, University of Toronto, Canada.
Biol Psychiatry. 1990 Sep 15;28(6):518-21. doi: 10.1016/0006-3223(90)90485-k.
The authors present a case report of neuroleptic malignant syndrome (NMS) in a patient commencing treatment with fluoxetine alone who had previously been treated with several antipsychotic and antidepressant combinations. On reviewing the literature on the pathogenesis of NMS, the authors hypothesize a facilitative role of the neurotransmitter serotonin (5-HT) in conjunction with central dopaminergic blockade in the precipitation of NMS.
作者报告了一例单独开始使用氟西汀治疗的患者发生抗精神病药恶性综合征（NMS）的病例，该患者此前曾接受过多种抗精神病药和抗抑郁药联合治疗。在回顾关于NMS发病机制的文献时，作者推测神经递质5-羟色胺（5-HT）与中枢多巴胺能阻滞在NMS的诱发中起协同促进作用。
