Department of Health Sciences, Section of Psychiatry, University of Pavia, Pavia, Italy.
Curr Pharm Des. 2012;18(4):505-9. doi: 10.2174/138161212799316000.
Recent years have witnessed numerous attempts at identifying the biological correlates of impending psychosis. Biochemical markers may theoretically provide a powerful approach to identify at-risk individuals, potentially leading to more effective intervention strategies to treat them. Hopefully, future developments in the field of research biochemistry in patients with at risk mental states or prodromal symptoms will make this approach ideal for screening and monitoring purposes. In this review, we provide an overview of the different biochemical markers which have been recently demonstrated to be altered in the biological fluids of patients with impending psychosis. We will also examine the practical issues that seem to be limiting the effective integration of biomarkers into clinical development.
近年来，人们尝试了许多方法来确定即将出现的精神病的生物学相关性。从理论上讲，生化标志物可能为识别高危个体提供一种强有力的方法，从而可能为治疗他们提供更有效的干预策略。希望在有风险的精神状态或前驱症状的患者的研究生物化学领域的未来发展将使这种方法成为筛选和监测的理想方法。在这篇综述中，我们概述了最近在即将出现精神病的患者的生物液中显示出改变的不同生化标志物。我们还将研究似乎限制生物标志物有效整合到临床开发中的实际问题。
