Psychother Res. 2000 Feb 1;10(2):215-34. doi: 10.1080/713663676.
Prior analyses of data from the NIMH sponsored Treatment for Depression Collaborative Research Program (TDCRP; e.g., Elkin, 1994) indicated greater reduction of symptoms at midtreatment (eighth week) with Imipramine (IMI-CM) than with Cognitive-behavioral therapy (CBT) and Interpersonal therapy (IPT), but no significant differences in symptom reduction among these three active treatments at termination. Current analyses of previously unanalyzed data from ratings by therapists, clinical evaluators, and patients at termination and at 18-month follow-up also indicated no significant differences among these treatments in symptom reduction or ratings of current clinical condition. But significant treatment differences emerged at the 18-month follow-up in patients' ratings of the effects of treatment on their life adjustment. Patients in IPT reported greater satisfaction with treatment, and patients in both IPT and CBT reported significantly greater effects of treatment on their capacity to establish and maintain interpersonal relationships and to recognize and understand sources of their depression than did patients in IMI-CM or placebo.
先前对 NIMH 赞助的抑郁症治疗合作研究计划（TDCRP；例如，Elkin，1994）数据的分析表明，在治疗中期（第八周），丙咪嗪（IMI-CM）比认知行为疗法（CBT）和人际关系疗法（IPT）更能减轻症状，但这三种有效治疗方法在治疗结束时，症状减轻没有显著差异。目前对来自治疗师、临床评估师和患者在治疗结束时和 18 个月随访时的评分的以前未分析数据的分析也表明，这些治疗方法在症状减轻或当前临床状况的评分方面没有显著差异。但在 18 个月的随访中，患者对治疗对生活调整的影响的评价出现了显著的治疗差异。IPT 组的患者对治疗的满意度更高，IPT 和 CBT 组的患者报告称，治疗对他们建立和维持人际关系的能力以及对识别和理解他们抑郁的原因的影响明显大于 IMI-CM 或安慰剂组的患者。
