Klinikum rechts der Isar, Department of Neurology, Technical University Munich, Ismaninger, Munich, Germany.
Ann N Y Acad Sci. 2012 Jan;1247:34-45. doi: 10.1111/j.1749-6632.2011.06355.x. Epub 2012 Jan 12.
Interleukin (IL) 17 is a phylogenetically ancient cytokine that has been adopted by the adaptive immune system, and the investigation of adaptive T helper (Th) 17 cells has substantially contributed to our understanding of the molecular requirements for the induction, regulation, and function of IL-17. However, IL-17 is in fact produced by a large variety of innate immune cells and exerts its most significant biological functions at the interface of the organism with its environment, such as, for example, at epithelial surfaces, where γδ T cells are a prominent source of IL-17. In this review, we will give an overview on the concepts of commitment of γδ T cells to effector phenotypes, focusing on IL-17-producing γδ T cells (γδT17 cells). The role of γδT17 cells in animal models of autoimmunity will be discussed as well as the prerequisites for the development of human γδT17 cells and their potential importance for human disease conditions.
白细胞介素 (IL) 17 是一种进化上古老的细胞因子，已被适应性免疫系统采用，对适应性辅助性 T 细胞 (Th) 17 细胞的研究极大地促进了我们对诱导、调节和 IL-17 功能的分子要求的理解。然而，IL-17 实际上是由多种先天免疫细胞产生的，并在生物体与其环境的界面处发挥其最重要的生物学功能，例如，在上皮表面，γδ T 细胞是 IL-17 的主要来源。在这篇综述中，我们将概述 γδ T 细胞向效应表型的分化的概念，重点介绍产生白细胞介素-17 的 γδ T 细胞 (γδT17 细胞)。还将讨论 γδT17 细胞在自身免疫动物模型中的作用，以及人类 γδT17 细胞发育的前提条件及其对人类疾病状况的潜在重要性。
