Department of Obstetrics and Gynecology, Kandang Kerbau Hospital, Singapore.
Int J Gynaecol Obstet. 2012 Apr;117(1):15-7. doi: 10.1016/j.ijgo.2011.10.033. Epub 2012 Jan 10.
To audit our experience of the diagnosis and treatment of vaginal intraepithelial neoplasia (VAIN) in Kandang Kerbau Women's Hospital, Singapore.
The clinical records of the patients diagnosed as having VAIN at our institution in the calendar year 2009 were periodically reviewed until March 2011.
There were 21 cases of VAIN. The mean follow-up duration was 18.2 months. The lesion grades were VAIN 1 in 9 patients (42.9%), VAIN 2 in 9 patients (42.9%), and VAIN 3 in 3 patients (14.3%). The mean patient age was 39.1 years. Sixteen patients (76.2%) were referred to our institution because of abnormal results to cytology tests and 4 patients (21.9%) were referred because of vaginal warts. The remaining patient was diagnosed from a surgical specimen. The diagnosis involved a cytology test, a colposcopic examination, an acetowhite test, a Schiller test, and a colposcopy-directed biopsy. The treatments varied and included watchful waiting but carbon dioxide laser vaporization was used the most frequently.
After 6 months of follow-up 18 patients were considered cured, for an overall cure rate of 85.7%. Two patients wanted no treatment and disease remained persistent in 1 patient despite laser vaporization and intravaginal applications of imiquimod cream.
审核我们在新加坡坎丹格保妇女医院（Kandang Kerbau Women's Hospital）诊断和治疗阴道上皮内瘤变（VAIN）的经验。
定期回顾我院 2009 年确诊为 VAIN 的患者的临床记录，直至 2011 年 3 月。
共 21 例 VAIN 患者，平均随访时间为 18.2 个月。病变分级为 VAIN 1 级 9 例（42.9%），VAIN 2 级 9 例（42.9%），VAIN 3 级 3 例（14.3%）。平均年龄为 39.1 岁。16 例（76.2%）因细胞学检查异常结果转诊，4 例（21.9%）因阴道疣转诊，其余 1 例患者来自手术标本。诊断包括细胞学检查、阴道镜检查、醋酸白试验、Schiller 试验和阴道镜引导活检。治疗方法各异，包括密切观察，但最常使用二氧化碳激光汽化。
随访 6 个月后，18 例患者被认为治愈，总治愈率为 85.7%。2 例患者不希望治疗，1 例患者尽管进行了激光汽化和咪喹莫特乳膏阴道内应用，疾病仍持续存在。
