骨骼肌MRI在杜氏肌营养不良症诊断及疾病进展监测中的应用
Use of skeletal muscle MRI in diagnosis and monitoring disease progression in Duchenne muscular dystrophy.
作者信息
Finanger Erika L, Russman Barry, Forbes Sean C, Rooney William D, Walter Glenn A, Vandenborne Krista
机构信息
Department of Pediatrics, Oregon Health and Science University, Portland, OR 97239, USA.
出版信息
Phys Med Rehabil Clin N Am. 2012 Feb;23(1):1-10, ix. doi: 10.1016/j.pmr.2011.11.004. Epub 2011 Dec 14.
Abstract
Studies have shown promise in using various approaches of magnetic resonance imaging (MRI) and magnetic resonance spectroscopy to evaluate skeletal muscle involvement in Duchenne muscular dystrophy. However, these studies have mainly been performed using a cross-sectional design, and the correlation of these MRI changes with disease progression and disease severity has not been fully elucidated. Overall, skeletal muscle MRI is a powerful and sensitive technique in the evaluation of muscle disease, and its use as a biomarker for disease progression or therapeutic response in clinical trials deserves further study.
摘要
研究表明，使用各种磁共振成像（MRI）和磁共振波谱方法来评估杜氏肌营养不良症中的骨骼肌受累情况具有前景。然而，这些研究主要采用横断面设计，且这些MRI变化与疾病进展和疾病严重程度之间的相关性尚未完全阐明。总体而言，骨骼肌MRI在评估肌肉疾病方面是一种强大且敏感的技术，其在临床试验中作为疾病进展或治疗反应的生物标志物的应用值得进一步研究。
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