Department of Radiology, Thomas Jefferson University, Philadelphia, Pennsylvania, USA.
JACC Cardiovasc Imaging. 2012 Jan;5(1):87-92. doi: 10.1016/j.jcmg.2011.08.017.
To develop a new noninvasive approach to quantify left ventricular (LV) pressures using subharmonic emissions from microbubbles, an ultrasound scanner was used in pulse inversion grayscale mode; unprocessed radiofrequency data were obtained with pulsed wave Doppler from the aorta and/or LV during Sonazoid infusion. Subharmonic data (in dB) were extracted and processed. Calibration factor (mm Hg/dB) from the aortic pressure was used to estimate LV pressures. Errors ranged from 0.19 to 2.50 mm Hg when estimating pressures using the aortic calibration factor, and were higher (0.64 to 8.98 mm Hg) using a mean aortic calibration factor. Subharmonic emissions from ultrasound contrast agents have the potential to noninvasively monitor LV pressures.
为了开发一种新的无创方法，使用微泡的次谐波发射来定量左心室（LV）压力，使用超声扫描仪在脉冲反转灰度模式下工作；在 SonoVue 输注期间，使用脉冲波多普勒从主动脉和/或 LV 获得未处理的射频数据。提取和处理次谐波数据（dB）。使用主动脉压力的校准因子（mmHg/dB）来估计 LV 压力。使用主动脉校准因子估计压力时，误差范围为 0.19 至 2.50 mmHg，使用平均主动脉校准因子时误差更高（0.64 至 8.98 mmHg）。超声造影剂的次谐波发射有可能无创监测 LV 压力。
