基于人群的研究：探讨台湾地区胃溃疡与勃起功能障碍之间的关联。
A population-based study on the association between gastric ulcers and erectile dysfunction in Taiwan.
机构信息
School of Medical Laboratory Sciences and Biotechnology, Taipei Medical University, Taipei, Taiwan.
出版信息
J Sex Med. 2012 Mar;9(3):686-93. doi: 10.1111/j.1743-6109.2011.02614.x. Epub 2012 Jan 12.
INTRODUCTION
While erectile dysfunction (ED) and cardiovascular disease have long been known to share endothelial dysfunction as a common contributory underlying mechanism, little research has been conducted taking endothelial dysfunction as common ground to investigate the potential association between ED and gastric ulcers (GUs).
AIM
This population-based case-control study aimed to investigate the association of ED with GU.
METHODS
This study used data from the Longitudinal Health Insurance Database 2000 in Taiwan. The study group comprised 6,906 patients who visited ambulatory care centers or were hospitalized with a diagnosis of ED. The comparison group was 20,718 randomly selected enrollees. Conditional logistic regression was used to examine associations between ED and prior GU.
MAIN OUTCOME MEASURE
The prevalence and risk between cases and controls were calculated of having been previously diagnosed with GU.
RESULTS
Of the sampled subjects, 3,861 (14%) were diagnosed before the index date, 1,358 (19.7%) were cases, and 2,503 (12.1%) were controls (P<0.001). After adjusting for hypertension, diabetes, hyperlipidemia, renal disease, coronary heart disease, obesity, alcohol abuse/alcohol dependence syndrome, and socioeconomic status (SES), conditional logistic regression analysis revealed that cases were more likely to have been diagnosed with GU than controls (odds ratio [OR]=1.65, 95% confidence interval [CI]=1.53-1.77). Stratification by age revealed that the youngest group (18-29) of ED patients had the most increased likelihood of having been previously diagnosed with GU when compared with matched controls (OR=4.12, 95% CI=2.41-7.03). The likelihood decreased with age, with the oldest group of ED patients having the least increased likelihood of prior GU when compared with matched controls (OR=1.44, 95%CI=1.23-1.68).
CONCLUSION
Our findings suggest a positive association between prior GU and a subsequent diagnosis with ED.
简介
虽然勃起功能障碍（ED）和心血管疾病长期以来一直被认为具有共同的内皮功能障碍的潜在机制，但很少有研究以内皮功能障碍为共同基础来探讨 ED 和胃溃疡（GU）之间的潜在关联。
目的
本基于人群的病例对照研究旨在探讨 ED 与 GU 之间的关系。
方法
本研究使用了来自台湾纵向健康保险数据库 2000 年的数据。研究组包括 6906 名因 ED 就诊于门诊或住院的患者。对照组是 20718 名随机选择的参保人。使用条件逻辑回归来检验 ED 与既往 GU 之间的关联。
主要观察指标
计算病例组和对照组之间既往 GU 诊断的患病率和风险比。
结果
在抽样对象中，3861 人（14%）在索引日期前被诊断出患有 GU，1358 人（19.7%）为病例，2503 人（12.1%）为对照组（P<0.001）。在调整了高血压、糖尿病、高血脂、肾脏疾病、冠心病、肥胖、酒精滥用/酒精依赖综合征和社会经济地位（SES）后，条件逻辑回归分析显示，病例组比对照组更有可能被诊断为 GU（比值比[OR]=1.65，95%置信区间[CI]=1.53-1.77）。按年龄分层显示，与匹配对照组相比，年龄最小的 ED 患者（18-29 岁）既往 GU 的诊断可能性增加最多（OR=4.12，95%CI=2.41-7.03）。这种可能性随着年龄的增加而降低，与匹配对照组相比，年龄最大的 ED 患者既往 GU 的可能性增加最小（OR=1.44，95%CI=1.23-1.68）。
结论
我们的研究结果表明，既往 GU 与随后 ED 的诊断呈正相关。
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