Division of Urology, Department of Surgery, Far Eastern Memorial Hospital, Ban Ciao, Taipei, Taiwan.
J Sex Med. 2012 Mar;9(3):679-85. doi: 10.1111/j.1743-6109.2011.02587.x. Epub 2012 Jan 12.
Some studies have highlighted the high prevalence of erectile dysfunction (ED) in patients with dermatological diseases such as psoriasis, chronic hand eczema, and systemic sclerosis. However, to date, there is still no study that has explored the relationship between ED and atopic dermatitis (AD).
Using a population-based data set, this case-control study aimed to examine the association of ED with prior AD by comparing the risk of prior AD between patients with ED and matched controls in Taiwan.
This study used administrative claims data from the Taiwan National Health Insurance program. We identified 3,997 patients with newly diagnosed ED as cases and randomly selected 19,985 subjects without a history of ED as controls. Conditional logistic regression was used to calculate the odds ratio (OR) and corresponding 95% confidence interval (CI) for previously diagnosed AD between cases and controls.
The prevalence and risk of having been previously diagnosed with AD between cases and controls were calculated.
Of the 23,982 sampled subjects, 1,758 (7.3%) had been previously diagnosed with AD; it was found among 425 (10.6%) cases and among 1,333 (6.7%) controls (P<0.001). Conditional logistic regression analysis demonstrated that cases were more likely to have prior AD than controls (OR=1.60, 95% CI=1.42-1.80, P<0.001) after adjusting for monthly income, geographic location, urbanization level, hypertension, diabetes, coronary heart disease, hyperlipidemia, obesity, and alcohol abuse/alcohol dependence syndrome.
There was an association between ED and prior AD. We suggest that clinicians should be more attentive to sexual complaints from patients with AD.
一些研究强调了患有皮肤病如银屑病、慢性手部湿疹和系统性硬化症的患者中勃起功能障碍（ED）的高发率。然而，迄今为止，仍没有研究探讨 ED 与特应性皮炎（AD）之间的关系。
本病例对照研究使用基于人群的数据集，通过比较台湾地区 ED 患者和匹配对照者中既往 AD 的风险，旨在研究 ED 与既往 AD 之间的关系。
本研究使用了来自台湾全民健康保险计划的行政索赔数据。我们确定了 3997 名新诊断为 ED 的患者作为病例，并随机选择了 19985 名无 ED 病史的患者作为对照。使用条件逻辑回归计算病例和对照者之间既往 AD 诊断的比值比（OR）及其 95%置信区间（CI）。
计算病例和对照者中 AD 的既往患病率和风险。
在 23982 名抽样受试者中，有 1758 名（7.3%）被诊断为 AD；其中 425 名（10.6%）病例和 1333 名（6.7%）对照者（P<0.001）有过既往 AD 诊断。条件逻辑回归分析表明，在调整了月收入、地理位置、城市化水平、高血压、糖尿病、冠心病、高脂血症、肥胖和酒精滥用/依赖综合征后，病例比对照者更有可能有过既往 AD（OR=1.60，95%CI=1.42-1.80，P<0.001）。
ED 与既往 AD 之间存在关联。我们建议临床医生应对 AD 患者的性抱怨更加关注。
