Denglehem C, Maes J-M, Raoul G, Ferri J
Département Universitaire de Chirurgie Maxillo-Faciale et Stomatologie, Hôpital Roger-Salengro, CHRU de Lille, boulevard du Professeur-Émile-Laine, 59000 Lille, France.
Rev Stomatol Chir Maxillofac. 2012 Feb;113(1):27-31. doi: 10.1016/j.stomax.2011.12.003. Epub 2012 Jan 10.
Pain, along with clicking, sub-luxation, and blocking, is one of the main symptoms for patients presenting with temporomandibular joint disorders. We assessed the effectiveness of botulinum toxin A (BOTOX(®), Allergan) as analgesic treatment for temporomandibular joint disorders.
Twenty-six patients with chronic pain linked to temporomandibular joint disorders were prospectively assessed. Botulinum toxin A was injected in masseter and temporalis muscles. Follow-up parameters, at one and three months, were: measuring mouth opening and diduction, muscle tenderness and pain using a visual analogue scale.
There was a significant (P<0.0001) decrease of pain, an increased mouth opening, and diduction at three months. Seventy percent of the patients felt less muscle tenderness. The patient felt his psychological state had improved and so did his family.
Botulinum toxin A significantly decreases pain and improves movements of patients presenting with temporomandibular joint disorders. The effects are prolonged three months after the injection.
疼痛连同弹响、半脱位及绞锁一起，是颞下颌关节紊乱症患者的主要症状之一。我们评估了A型肉毒毒素（保妥适，艾尔建公司）作为颞下颌关节紊乱症镇痛治疗方法的有效性。
对26例与颞下颌关节紊乱症相关的慢性疼痛患者进行前瞻性评估。将A型肉毒毒素注射到咬肌和颞肌中。1个月和3个月时的随访参数包括：测量开口度和下颌运动度，使用视觉模拟量表评估肌肉压痛和疼痛程度。
3个月时疼痛显著减轻（P<0.0001），开口度和下颌运动度增加。70%的患者肌肉压痛减轻。患者感觉其心理状态有所改善，其家人也有同感。
A型肉毒毒素可显著减轻颞下颌关节紊乱症患者的疼痛并改善其运动功能。注射后效果可持续3个月。
