锂对甲状旁腺激素诱导的骨原基钙释放的影响。

Effect of lithium on parathyroid hormone-induced calcium release from bone rudiments.

作者信息

Baran D T, Burks J K, Richardson C A, Hamilton J B, Halstead L R, Hahn T J, Teitelbaum S L, Avioli L V

出版信息

Calcif Tissue Int. 1979 Apr 17;27(2):127-8. doi: 10.1007/BF02441174.

Abstract

Lithium treatment of humans and animals has been associated with adverse effects on bone and mineral metabolism. In order to determine whether lithium was altering the skeletal response to parathyroid hormone, we incubated bone rudiments for 5 days in the presence or absence of the drugs. Lithium had no effect on either parathyroid hormone-induced cyclic AMP generation or 45Ca release from the bone rudiments. The data are consistent with the hypothesis that the skeletal effects of lithium are not mediated via inhibition of the parathyroid hormone-adenyl cyclase-cyclic AMP system.

摘要

对人类和动物进行锂治疗已发现其对骨骼和矿物质代谢有不良影响。为了确定锂是否会改变骨骼对甲状旁腺激素的反应，我们将骨雏形在有或无药物存在的情况下孵育5天。锂对甲状旁腺激素诱导的环磷酸腺苷（cAMP）生成或骨雏形中45钙的释放均无影响。这些数据与以下假设一致，即锂对骨骼的影响并非通过抑制甲状旁腺激素-腺苷酸环化酶-环磷酸腺苷系统介导。