Baran D T, Schwartz M P, Bergfeld M A, Teitelbaum S L, Slatopolsky E, Avioli L V
J Clin Invest. 1978 Jun;61(6):1691-6. doi: 10.1172/JCI109090.
Lithium chloride administration to growing rats, which resulted in circulating lithium levels of 1.4 meq/liter, was attended by significant suppression of bone mineralization and organic matrix synthesis as assessed by tetracycline labeling and histological quantitation of osteoid, respectively. These effects of lithium were not associated with changes in animal behavior, nor were there any significant differences in blood levels of calcium, phosphorus, alkaline phosphatase, creatinine, pH, or parathyroid hormone. The data suggest that lithium inhibition of bone mineralization is secondary to suppression of osteoid formation.
给生长中的大鼠施用氯化锂，使其循环锂水平达到1.4毫当量/升，结果通过四环素标记和类骨质的组织学定量评估发现，骨矿化和有机基质合成受到显著抑制。锂的这些作用与动物行为的变化无关，血液中的钙、磷、碱性磷酸酶、肌酐、pH值或甲状旁腺激素水平也没有显著差异。数据表明，锂对骨矿化的抑制作用继发于对类骨质形成的抑制。
