Wilkinson L J, White R J, Chipman J K
School of Biosciences, The University of Birmingham, UK.
J Wound Care. 2011 Nov;20(11):543-9. doi: 10.12968/jowc.2011.20.11.543.
Wound infections present a significant clinical challenge, impacting on patient morbidity and mortality, with significant economic implications. Silver-impregnated wound dressings have the potential to reduce both wound bioburden and healing time. The silver ion Ag+ is the active antimicrobial entity; it can interfere with thiol (-SH) groups and provoke the generation of reactive oxygen species (ROS), a major contributor to its antibacterial efficacy. Recently, silver nanoparticles have gained considerable interest in wound bioburden reduction and in anti-inflammation, as they can release Ag+ ions at a greater rate than bulk silver, by virtue of their large surface area. If released from dressings, they also have the potential to cross biological compartments. This review aims to consolidate recent findings as to the efficacy and safety of different formulations of silver used as an antiseptic agent in dressings, summarising the features of silver nanomaterials, with particular attention to the dose-dependencies for biological effects, highlighting the need for information on their uptake and potential biological effects.
伤口感染带来了重大的临床挑战，影响患者的发病率和死亡率，并产生重大的经济影响。含银伤口敷料有潜力降低伤口生物负荷并缩短愈合时间。银离子Ag+是具有抗菌活性的实体；它能干扰硫醇（-SH）基团并引发活性氧（ROS）的产生，这是其抗菌功效的主要贡献因素。最近，银纳米颗粒在减少伤口生物负荷和抗炎方面引起了相当大的关注，因为它们凭借大表面积能够比块状银以更高的速率释放Ag+离子。如果从敷料中释放出来，它们还有可能穿过生物区室。本综述旨在汇总关于用作敷料防腐剂的不同银制剂的功效和安全性的最新研究结果，总结银纳米材料的特性，特别关注其生物效应的剂量依赖性，强调需要有关其摄取和潜在生物效应的信息。
