Lu Shuangyun, Gao Wenjuan, Gu Hai Ying
Institute of Analytical Chemistry for Life Science, School of Public Health, Nantong University, Nantong 226007, China.
Burns. 2008 Aug;34(5):623-8. doi: 10.1016/j.burns.2007.08.020. Epub 2008 Jan 15.
A novel wound dressing composed of nano-silver and chitosan was fabricated using a nanometer and self-assembly technology. Sterility and pyrogen testing assessed biosafety, and efficacy was evaluated using Sprague-Dawley rats with deep partial-thickness wounds. Silver sulfadiazine and chitosan film dressings were used as controls. At intervals wound areas were measured, wound tissues biopsied and blood samples taken. Compared with the controls, the silver nanocrystalline chitosan dressing significantly (p<0.01) increased the rate of wound healing and was associated with silver levels in blood and tissues lower than levels associated with the silver sulfadiazine dressing (p<0.01). Sterility and pyrogen tests of the silver nanocrystalline chitosan dressing were negative. Thus this dressing should have wide application in clinical settings.
采用纳米和自组装技术制备了一种由纳米银和壳聚糖组成的新型伤口敷料。通过无菌和热原测试评估生物安全性，并使用患有深度部分厚度伤口的Sprague-Dawley大鼠评估疗效。磺胺嘧啶银和壳聚糖薄膜敷料用作对照。定期测量伤口面积，对伤口组织进行活检并采集血样。与对照组相比，银纳米晶壳聚糖敷料显著（p<0.01）提高了伤口愈合率，且血液和组织中的银含量低于与磺胺嘧啶银敷料相关的水平（p<0.01）。银纳米晶壳聚糖敷料的无菌和热原测试均为阴性。因此，这种敷料在临床环境中应具有广泛的应用。
