质子泵抑制剂引起的粒细胞缺乏症。
Agranulocytosis induced by proton pump inhibitors.
机构信息
Department of Respiratory Medicine, University Hospital of Reims, Reims, France.
出版信息
J Clin Gastroenterol. 2012 Nov-Dec;46(10):859. doi: 10.1097/MCG.0b013e318236f18a.
PMID:22240865
Abstract
We report the first published case of agranulocytosis induced by omeprazole and its recurrence with esomeprazole, the S-isomer form of omeprazole. Interestingly, we found an homozygotous mutation of CYP2C19*17, responsible for the metabolism of proton pump inhibitors.
摘要
我们报告了首例奥美拉唑引起的粒细胞缺乏症病例，以及奥美拉唑 S-对映异构体埃索美拉唑再次引发该病症的首例报道。有趣的是，我们发现了导致质子泵抑制剂代谢的 CYP2C19*17 纯合突变。
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