Yu Zheng, Hu Jing, Hu Yaojun
Department of Gastroenterology, Fuxing Hospital, the Eighth Clinical Medical College, Capital Medical University, #20, Fuxingmenwai Street, Xicheng District, Beijing, China.
Drug Saf Case Rep. 2018 Nov 23;5(1):28. doi: 10.1007/s40800-018-0093-0.
An 85-year-old man was admitted to our hospital because of dysphagia, and was diagnosed with benign stricture of the esophagus. He was hospitalized repeatedly for balloon dilations. Pantoprazole sodium (80 mg, twice daily, intravenously) was administered each time when he was in hospital, while esomeprazole (20 mg/day, orally) was administered intermittently when he was at home. Reductions in both white blood cells and platelets were noticed about 4 months after proton pump inhibitors were introduced. Bone marrow suppression induced by proton pump inhibitors was diagnosed as proven by bone marrow biopsy. White blood cell, neutrophil, and platelet counts went back to the normal range after proton pump inhibitors were stopped. The present case shows a rare bi-cytopenia associated with proton pump inhibitors and suggests the importance of awareness of hematological adverse events during proton pump inhibitor therapy.
一名85岁男性因吞咽困难入院，被诊断为食管良性狭窄。他因气囊扩张术多次住院。每次住院时静脉注射泮托拉唑钠（80毫克，每日两次），在家时则间歇口服埃索美拉唑（20毫克/天）。在使用质子泵抑制剂约4个月后，发现白细胞和血小板均减少。经骨髓活检证实，诊断为质子泵抑制剂所致的骨髓抑制。停用质子泵抑制剂后，白细胞、中性粒细胞和血小板计数恢复到正常范围。本病例显示了一种罕见的与质子泵抑制剂相关的双血细胞减少症，并提示在质子泵抑制剂治疗期间认识血液学不良事件的重要性。
