[移植性肿瘤生长过程中小鼠红细胞中嘌呤化合物的代谢池]
[Metabolic pool of purine compounds in erythrocytes of mice during growth of transplanted tumors].
作者信息
Tikhonov Iu V, Pimenov A M, Toguzov R T, Zims V, Grune T, Shmidt Kh, Gerber G
机构信息
Children Hospital, Medical Faculty (Charite), Humboldt University, Berlin.
出版信息
Biull Eksp Biol Med. 1990 Jul;110(7):39-40.
The pattern of purine derivatives was studied in the erythrocytes of C3HA and ICR mice during Hepatoma 22 and Ehrlich ascites tumor cells growth. Host erythrocytes purine nucleotides, nucleosides and bases were affected by the implanted tumors. The results indicated that the host erythrocytes markedly concentrated adenine and guanine nucleotides on the 5th and 11th-12th day of tumor growth. By contrast, content of nucleosides and bases were sharply decreased during the log growth phase (5th day) with the restoring of these precursors within the 11th-12th day (plateau phase). These observations indicate that aspects of the purine compounds metabolism in host erythrocytes are linked with tumor development.
在肝癌22和艾氏腹水瘤细胞生长期间，对C3HA和ICR小鼠红细胞中的嘌呤衍生物模式进行了研究。植入的肿瘤会影响宿主红细胞中的嘌呤核苷酸、核苷和碱基。结果表明，在肿瘤生长的第5天和第11 - 12天，宿主红细胞显著浓缩腺嘌呤和鸟嘌呤核苷酸。相比之下，核苷和碱基的含量在对数生长期（第5天）急剧下降，并在第11 - 12天（平台期）恢复到这些前体物质的水平。这些观察结果表明，宿主红细胞中嘌呤化合物代谢的各个方面与肿瘤发展有关。
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