Tikhonov Y V, Pimenov A M, Toguzov R T, Grune T, Siems W, Schmidt H, Gerber G
Department of Biochemistry, N. I Pirogov 2nd Medical Institute, Moscow, USSR.
Biomed Biochim Acta. 1990;49(2-3):S125-8.
The pattern of purine and pyrimidine derivatives was studied in the erythrocytes of C3HA and ICR mice during Hepatoma 22 and Ehrlich ascites tumor cell growth. Concentrations of purine nucleotides, nucleosides and nucleobases of host erythrocytes were changed after the implantation of the tumors. The host erythrocytes markedly concentrated adenine and guanine nucleotides both during logarithmic and plateau phase of tumor growth (5th and 11-12th days after inoculation of the tumor). The contents of nucleosides and nucleobases in the red blood cells were decreased during the logarithmic growth phase but restored within the plateau phase.
在肝癌22和艾氏腹水瘤细胞生长期间，对C3HA和ICR小鼠红细胞中的嘌呤和嘧啶衍生物模式进行了研究。肿瘤植入后，宿主红细胞中嘌呤核苷酸、核苷和核碱基的浓度发生了变化。在肿瘤生长的对数期和平稳期（接种肿瘤后第5天和第11 - 12天），宿主红细胞均显著浓缩腺嘌呤和鸟嘌呤核苷酸。红细胞中核苷和核碱基的含量在对数生长期降低，但在平稳期恢复。
