作为生物分子和细胞探针的发光无机和有机过渡金属配合物的应用。
Applications of luminescent inorganic and organometallic transition metal complexes as biomolecular and cellular probes.
机构信息
Department of Biology and Chemistry, City University of Hong Kong, Tat Chee Avenue, Kowloon, Hong Kong, P. R. China.
出版信息
Dalton Trans. 2012 May 28;41(20):6021-47. doi: 10.1039/c2dt11892k. Epub 2012 Jan 13.
The rich photophysical properties of luminescent inorganic and organometallic transition metal complexes, such as their intense, long-lived, and environment-sensitive emission, render them excellent candidates for biological and cellular studies. In this Perspective, we review examples of biological probes derived from luminescent transition metal complexes with a d(6), d(8), or d(10) metal center. The design of luminescent covalent labels and noncovalent probes for protein molecules is discussed. Additionally, the recent applications of these complexes as cellular probes and bioimaging reagents are described. Emphasis is put on the structural features, photophysical behavior, biomolecular interactions, cellular uptake, and intracellular localization properties of luminescent transition metal complexes.
发光无机和有机过渡金属配合物具有丰富的光物理性质，例如强烈、长寿命和对环境敏感的发射，这使它们成为生物和细胞研究的优秀候选物。在本观点中，我们回顾了源自具有 d(6)、d(8)或 d(10)金属中心的发光过渡金属配合物的生物探针的实例。讨论了用于蛋白质分子的发光共价标记和非共价探针的设计。此外，还描述了这些配合物作为细胞探针和生物成像试剂的最新应用。重点介绍了发光过渡金属配合物的结构特征、光物理行为、生物分子相互作用、细胞摄取和细胞内定位特性。
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