阿尔茨海默病的多模态成像。MRI、SPECT、认知与病理变化之间的关系。

Multimodal imaging in Alzheimer's disease. The relationship between MRI, SPECT, cognitive and pathological changes.

作者信息

Besson J A, Crawford J R, Parker D M, Ebmeier K P, Best P V, Gemmell H G, Sharp P F, Smith F W

机构信息

Department of Mental Health, University of Aberdeen, Foresterhill.

出版信息

Br J Psychiatry. 1990 Aug;157:216-20. doi: 10.1192/bjp.157.2.216.

DOI:10.1192/bjp.157.2.216

PMID:2224371

Abstract

Patients with a clinical diagnosis of Alzheimer's disease were studied using MRI, SPECT, and psychometric tests. Significant correlations between focal perfusion deficits and focal cognitive deficits were found. Significant correlations between regional relaxation time of white matter and psychometric tests of diffuse and focal categories were also found. Pathological examination confirmed Alzheimer's disease as the only diagnosis.

摘要

对临床诊断为阿尔茨海默病的患者进行了磁共振成像（MRI）、单光子发射计算机断层扫描（SPECT）和心理测量测试。发现局部灌注缺陷与局部认知缺陷之间存在显著相关性。还发现白质区域弛豫时间与弥漫性和局灶性类别的心理测量测试之间存在显著相关性。病理检查证实阿尔茨海默病为唯一诊断。