Division of Neurosurgery, Department of Surgery, Prince of Wales Hospital, 4/F, Clinical Science Building, The Chinese University of Hong Kong, 1 Ngan Shing Street, Shatin, New Territories, Hong Kong, China.
J Clin Neurosci. 2012 Feb;19(2):222-3. doi: 10.1016/j.jocn.2011.07.019. Epub 2012 Jan 12.
In view of the early results and halt of recruitment from both the Carotid Occlusion Surgery Study (COSS) and Stenting and the Aggressive Medical Therapy for Preventing Recurrent Stroke in Intracranial Stenosis (SAMMPRIS) study we should seize this opportunity to reflect on future directions, rather than abandoning these procedures, during this period of disillusionment. We here suggest the reasons for the failure of these two clinical trials and review future directions for researche in cerebral revascularization.
鉴于颈动脉血管阻塞手术研究(COSS)和支架置入与强化药物治疗预防颅内狭窄患者卒中复发研究(SAMMPRIS)这两项研究的早期结果和入组停滞,我们应该抓住这个机会进行反思,在这个幻想破灭的时期,我们不应该摒弃这些治疗方法,而是思考未来的发展方向。在此,我们提出了这两项临床试验失败的原因,并对脑血运重建研究的未来方向进行了综述。