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关于动物模型的鱼类、两栖动物、爬行动物、啮齿动物、兔形目动物和雪貂中的分枝杆菌病变

Mycobacterial lesions in fish, amphibians, reptiles, rodents, lagomorphs, and ferrets with reference to animal models.

作者信息

Reavill Drury R, Schmidt Robert E

机构信息

Zoo/Exotic Pathology Service, West Sacramento, CA 95605, USA.

出版信息

Vet Clin North Am Exot Anim Pract. 2012 Jan;15(1):25-40, v. doi: 10.1016/j.cvex.2011.10.001. Epub 2011 Dec 3.

DOI:10.1016/j.cvex.2011.10.001
PMID:22244111
Abstract

Mycobacteriosis is a serious disease across many animal species. Approximately more than 120 species are currently recognized in the genus Mycobacterium. This article describes the zoonotic potential of mycobacteria and mycobacteriosis in fish, amphibians, rodents, rabbits, and ferrets. It considers clinical signs; histology; molecular methods of identification, such as polymerase chain reaction and DNA sequencing; routes of infection; and disease progression. Studying the disease in animals may aid in understanding the pathogenesis of mycobacterial infections in humans and identify better therapy and preventative options such as vaccines.

摘要

分枝杆菌病是一种在许多动物物种中都很严重的疾病。目前在分枝杆菌属中已确认约120多个物种。本文描述了鱼类、两栖动物、啮齿动物、兔子和雪貂中分枝杆菌和分枝杆菌病的人畜共患病潜力。它考虑了临床症状;组织学;分子鉴定方法,如聚合酶链反应和DNA测序;感染途径;以及疾病进展。研究动物中的这种疾病可能有助于理解人类分枝杆菌感染的发病机制,并确定更好的治疗和预防选择,如疫苗。

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