Division of Allergy and Immunology, Department of Pediatrics, Mount Sinai School of Medicine, One Gustave L. Levy Place, New York, NY 10029, USA.
Immunol Allergy Clin North Am. 2012 Feb;32(1):67-81. doi: 10.1016/j.iac.2011.11.006. Epub 2011 Dec 16.
Eosinophilic esophagitis is a clinicopathologic disease that can present with a constellation of upper gastrointestinal symptoms and endoscopic findings in conjunction with significant infiltration of the esophageal tissue with eosinophils. Clinical and histologic resolution of the disease can be seen with dietary restriction therapies and systemic and topical corticosteroids. Because most patients have an atopic background and the disease seems to have an underlying T-helper type 2 pathogenesis, allergists and gastroenterologists need to be familiar with the diagnosis and management of this disease. In this review, clinical characteristics, endoscopic and histologic findings, and available therapy options are discussed.
嗜酸性粒细胞性食管炎是一种临床病理疾病，其特征为一系列上消化道症状和内镜检查结果，并伴有食管组织中嗜酸性粒细胞的大量浸润。通过饮食限制疗法以及全身和局部皮质类固醇治疗，可实现疾病的临床和组织学缓解。由于大多数患者具有特应性背景，并且该疾病似乎具有潜在的辅助性 T 细胞 2 发病机制，因此过敏症专家和胃肠病学家需要熟悉该疾病的诊断和治疗。在这篇综述中，讨论了临床特征、内镜和组织学发现以及可用的治疗选择。
