Bowyer R C, Cawthorn S J, Walker W J, Giddings A E
Royal Surrey County Hospital, Guildford, UK.
Br J Surg. 1990 Oct;77(10):1132-5. doi: 10.1002/bjs.1800771018.
Historical review shows that the treatment of popliteal aneurysm has developed by trial and error and there is disagreement about the proper management of the symptomless patient. In 1981 a policy of conservative management for asymptomatic popliteal aneurysm was adopted in this unit. Since that time we have also managed nine patients with thrombosed popliteal aneurysms by arteriography and low-dose intra-arterial streptokinase. Six patients treated within 72 h of occlusion achieved significant (70-100 per cent) lysis, but streptokinase was ineffective in those treated 10 or more days after the thrombosis. Of the six patients with significant lysis, three were treated by elective reconstruction and two by anticoagulation. One patient who had significant lysis died. Vascular patency of all five successfully treated limbs was maintained and no limb loss occurred in those who presented late and failed to achieve significant lysis. These results reinforce the view that thrombolysis is the treatment of choice for thrombosed popliteal aneurysms. The low complication rate for asymptomatic popliteal aneurysms and the advent of safe, effective thrombolysis indicate that operation for symptomless popliteal aneurysm is no longer required.
历史回顾表明,腘动脉瘤的治疗是通过反复试验发展而来的,对于无症状患者的恰当管理存在分歧。1981年,本单位采用了无症状腘动脉瘤的保守治疗策略。自那时起,我们还通过动脉造影和低剂量动脉内链激酶治疗了9例血栓形成的腘动脉瘤患者。在闭塞72小时内接受治疗的6例患者实现了显著(70% - 100%)的溶栓,但链激酶对血栓形成10天或更长时间后接受治疗的患者无效。在6例实现显著溶栓的患者中,3例接受了择期重建治疗,2例接受了抗凝治疗。1例实现显著溶栓的患者死亡。所有5例成功治疗的肢体均维持了血管通畅,那些就诊较晚且未实现显著溶栓的患者未发生肢体丢失。这些结果强化了这样一种观点,即溶栓是血栓形成的腘动脉瘤的首选治疗方法。无症状腘动脉瘤的低并发症发生率以及安全、有效溶栓方法的出现表明,无症状腘动脉瘤不再需要手术治疗。