急性肾损伤时的肾脏替代治疗剂量。
Dosing of renal replacement therapy in acute kidney injury.
机构信息
Renal Division, Washington University in St Louis School of Medicine, St Louis, MO, USA.
出版信息
Am J Kidney Dis. 2012 Apr;59(4):569-76. doi: 10.1053/j.ajkd.2011.11.035. Epub 2012 Jan 11.
Abstract
The impact of the intensity of renal replacement therapy on outcomes in patients with acute kidney injury has been studied intensively during the past decade. In this review, we consider the concept of dose of renal replacement therapy in acute kidney injury and summarize the recent clinical trials addressing this topic. Although several single-center trials suggest that more intensive therapy is associated with improved outcomes, 2 large multicenter randomized trials do not find a benefit with higher doses of therapy. Based on these studies, we provide recommendations for the delivered intensity of renal replacement therapy in acute kidney injury.
摘要
在过去的十年中，人们对肾脏替代疗法的强度对急性肾损伤患者结局的影响进行了深入研究。在这篇综述中，我们考虑了急性肾损伤中肾脏替代疗法剂量的概念，并总结了最近关于这一主题的临床试验。尽管一些单中心试验表明更强化的治疗与更好的结局相关，但 2 项大型多中心随机试验并未发现更高剂量治疗有获益。基于这些研究，我们为急性肾损伤中肾脏替代疗法的提供强度提供了建议。
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