Department of Psychiatry, Abramson Cancer Center, and Annenberg Public Policy Center, University of Pennsylvania, Philadelphia, PA 19104, United States.
Addict Behav. 2012 Apr;37(4):565-8. doi: 10.1016/j.addbeh.2011.12.009. Epub 2011 Dec 26.
People who quit smoking often gain 11-12 lb, on average, which can frequently lead to a relapse to smoking. This study evaluated whether extended vs. standard duration treatment with nicotine patch helps those able to quit smoking to reduce cessation-induced weight gain and explored nicotine patch adherence as a mediator of treatment effects.
We examined data from a completed randomized placebo-controlled clinical trial of extended (24 weeks) vs. standard (8 weeks plus 16 weeks of placebo) transdermal nicotine patch therapy. Changes in measured weight over 24 weeks were compared across the two treatment arms, controlling for gender, baseline smoking rate, and previous weight. Adherence to patch use was assessed using self-report of daily use over 24 weeks.
139 clinical trial participants who were confirmed to be abstinent at weeks 8 and 24.
Compared to participants who received 8 weeks of nicotine patch therapy, participants who received 24 weeks of treatment showed significantly less weight gain from pre-treatment to week 24 (β=-4.76, 95% CI: -7.68 to -1.84, p=.002) and significantly less weight gain from week 8 to week 24 (β=-2.31, 95% CI: -4.39 to -0.23, p=.03). Extended treatment increased patch adherence which, in turn, reduced weight gain; patch adherence accounted for 20% of the effect of treatment arm on weight gain.
Compared to 8 weeks of transdermal nicotine therapy, 24 weeks of patch treatment may help to reduce the weight gain that is typical among smokers who are able to achieve abstinence from tobacco use. Extended treatment increased nicotine patch adherence which, in turn, reduced weight gain.
戒烟者通常平均增重 11-12 磅，这往往会导致他们重新吸烟。本研究评估了尼古丁贴片延长（24 周）与标准（8 周加 16 周安慰剂）治疗时间对帮助戒烟者减少戒断引起的体重增加的作用，并探讨了尼古丁贴片的使用依从性是否为治疗效果的中介因素。
我们检查了一项已完成的随机安慰剂对照临床试验的数据，该试验比较了延长（24 周）和标准（8 周加 16 周安慰剂）透皮尼古丁贴片治疗。在控制性别、基线吸烟率和以前的体重后，比较了两个治疗组在 24 周内体重的变化。通过 24 周内每天使用贴片的自我报告来评估对贴片的使用依从性。
139 名经确认在第 8 周和第 24 周均未吸烟的临床试验参与者。
与接受 8 周尼古丁贴片治疗的参与者相比，接受 24 周治疗的参与者从治疗前到第 24 周体重增加明显较少（β=-4.76，95%CI：-7.68 至-1.84，p=.002），从第 8 周到第 24 周体重增加也明显较少（β=-2.31，95%CI：-4.39 至-0.23，p=.03）。延长治疗增加了贴片的使用依从性，从而减少了体重增加；贴片的使用依从性占治疗组对体重增加影响的 20%。
与 8 周的透皮尼古丁治疗相比，24 周的贴片治疗可能有助于减少能够戒除烟草的吸烟者中典型的体重增加。延长治疗增加了尼古丁贴片的使用依从性，从而减少了体重增加。
