Department of Ambulatory Care and Community Medicine, University of Lausanne, Lausanne, Switzerland.
Tob Control. 2010 Dec;19(6):488-94. doi: 10.1136/tc.2009.030288. Epub 2010 Aug 25.
Exercise combined with nicotine therapy may help smoking cessation and minimise weight gain after quitting. Low participation in vigorous-intensity physical activity programmes precludes their population-wide applicability. In a randomised controlled trial, we tested whether a population-based moderate-intensity physical activity programme increases quit rates among sedentary smokers receiving nicotine therapy.
Participants (n=481; 57% male; mean age, 42.2 years (SD 10.1); mean cigarette consumption, 27 (SD 10.2) per day) were offered a nine-week smoking cessation programme consisting of a weekly 15-minute counselling session and the prescription of nicotine replacement therapy. In addition, participants in the physical activity group (n=229) also took part in a programme of moderate-intensity physical activity implemented at the national level, and offering nine weekly 60-minute sessions of physical activity. To ensure equal contact conditions, participants in the control group (n=252) attended weekly 60-minute health behaviour education sessions unrelated to physical activity. The primary outcome was continuous CO-verified smoking abstinence rates at 1-year follow-up.
Continuous smoking abstinence rates were high and similar in the physical activity group and the control group at the end of the intervention (47% versus 46%, p=0.81) and at 1-year follow-up (27% versus 29%, p=0.71). The mean weight gain after one year was 4.4 kg and 6.2 kg among sustained quitters of the physical activity and control groups, respectively (p=0.06).
Participation in a population-based moderate-intensity physical activity programme for 9 weeks in addition to a comprehensive smoking cessation programme did not significantly increase smoking cessation rates. A non-significant reduction in weight gain was observed among participants who quit smoking in the physical activity group.
ClinicalTrials.gov; US National Institutes for Health (available online at http://clinicaltrials.gov/;
NCT00521391).
运动与尼古丁疗法联合应用可能有助于戒烟并最大程度减少戒烟后的体重增加。由于高强度体育活动方案参与率低,其在人群中的应用受到限制。我们在一项随机对照试验中,测试了一项基于人群的中等强度体育活动方案是否能提高正在接受尼古丁疗法的久坐吸烟者的戒烟率。
参与者(n=481;57%为男性;平均年龄为 42.2 岁(10.1 岁);平均每天吸烟 27(10.2)支)接受为期 9 周的戒烟计划,包括每周 15 分钟的咨询和尼古丁替代疗法的处方。此外,运动组(n=229)的参与者还参加了全国范围内实施的中等强度体育活动计划,该计划提供每周 60 分钟的体育活动。为了确保同等的接触条件,对照组(n=252)的参与者参加了每周 60 分钟与体育活动无关的健康行为教育课程。主要结局为 1 年随访时持续的 CO 验证的吸烟戒断率。
在干预结束时(47%比 46%,p=0.81)和 1 年随访时(27%比 29%,p=0.71),运动组和对照组的连续吸烟戒断率均较高且相似。持续戒烟者在 1 年后的体重平均增加 4.4 公斤和 6.2 公斤,分别为运动组和对照组(p=0.06)。
除综合戒烟计划外,参与基于人群的中等强度体育活动方案 9 周并没有显著提高戒烟率。在运动组中,戒烟的参与者体重增加有轻微减少。
ClinicalTrials.gov;美国国立卫生研究院(可在 http://clinicaltrials.gov/在线获取);
NCT00521391。