Ludwig Engel Centre for Respiratory Research, Sydney, NSW, Australia.
Respir Physiol Neurobiol. 2012 Mar 15;180(2-3):342-51. doi: 10.1016/j.resp.2011.12.012. Epub 2012 Jan 6.
Baroreflex sensitivity (BRS) is reduced in humans during snoring, however the mechanisms are unknown. We used an anaesthetised rabbit induced snoring (IS) model, to test: (1) whether IS was associated with reduced BRS; and (2) if snoring related vibration transmission to peri-carotid tissues influenced BRS levels. BRS was quantified using the spontaneous sequence technique. During IS, BRS fell by 40%, without any associated change in blood pressure (BP) but accompanied by an increase in heart rate (HR). Direct application of a snore frequency and intensity matched vibratory stimulus to the peri-carotid tissues of non-snoring tracheostomised rabbits had no effect on BRS, HR or BP. In conclusion, IS induced depression of BRS is likely mediated via a HR driven change in BRS operating point that is unrelated to snoring-related vibration transmission to carotid baroreceptors. The anaesthetised IS rabbit provides a model in which mechanistic interactions between snoring and BRS can be further explored.
压力反射敏感性（BRS）在人类打鼾时降低，但机制尚不清楚。我们使用麻醉兔诱导的打鼾（IS）模型来测试：（1）IS 是否与 BRS 降低有关；（2）如果与打鼾相关的振动传递到颈旁组织是否会影响 BRS 水平。使用自发性序列技术来量化 BRS。在 IS 期间，BRS 下降了 40%，而血压（BP）没有任何相关变化，但心率（HR）增加。将与打鼾频率和强度匹配的振动刺激直接施加到非打鼾气管切开兔的颈旁组织，对 BRS、HR 或 BP 没有影响。总之，IS 诱导的 BRS 降低可能是通过 HR 驱动的 BRS 工作点变化介导的，与打鼾相关的振动向颈动脉压力感受器的传递无关。麻醉 IS 兔提供了一个模型，可以进一步探索打鼾和 BRS 之间的机制相互作用。
