Ludwig Engel Centre for Respiratory Research, Department of Respiratory and Sleep Medicine, Sydney, NSW, Australia.
Respir Physiol Neurobiol. 2013 Feb 1;185(3):489-96. doi: 10.1016/j.resp.2012.11.011. Epub 2012 Dec 3.
Baroreflex sensitivity (BRS) is reduced during snoring in humans and animal models. We utilised our rabbit model to examine the contribution of increased upper airway resistance to baroreflex resetting during snoring, by comparing BRS and baroreflex operating point (OP) values during IS to those obtained during tracheostomised breathing through an external resistive load (RL) titrated to match IS levels of peak inspiratory pleural pressure (Ppl). During both IS and RL, BRS decreased by 45% and 49%. There was a linear relationship between the change in Ppl and the decrease in BRS, which was similar for IS and RL. During both RL and IS, there was a shift in OP driven by ~16% increase in HR and no change in arterial pressure. Snoring related depression of BRS is likely mediated via a HR driven change in OP, which itself may be the outcome of negative intra-thoracic pressure mediated effects on right atrial wall stretch reflex control of heart rate.
人体和动物模型在打鼾时的压力反射敏感性（BRS）降低。我们利用兔模型，通过比较在气道内正压通气（IS）期间和通过外部电阻负载（RL）进行气管切开呼吸时，针对吸气峰胸膜压力（Ppl）的 IS 水平滴定至匹配的 RL 值时的 BRS 和压力反射操作点（OP）值，来检查增加上呼吸道阻力对打鼾时压力反射重置的贡献。在 IS 和 RL 期间，BRS 分别降低了 45%和 49%。Ppl 的变化与 BRS 的降低之间存在线性关系，IS 和 RL 之间的关系相似。在 RL 和 IS 期间，OP 发生了变化，这主要是由于 HR 增加了约 16%，而动脉压没有变化。与打鼾相关的 BRS 抑制可能是通过 OP 驱动的 HR 变化介导的，而 OP 变化本身可能是负胸腔内压力对右心房壁伸展反射控制心率的影响的结果。
