分析多发性硬化症中接触蛋白-2 表面表位的抗体。
Analysis of antibodies to surface epitopes of contactin-2 in multiple sclerosis.
机构信息
Center for Neuroimmunology, Service of Neurology, Hospital Clinic and Institut d' Investigació Biomèdica August Pi i Sunyer, Universitat de Barcelona, Barcelona, Spain.
出版信息
J Neuroimmunol. 2012 Mar;244(1-2):103-6. doi: 10.1016/j.jneuroim.2011.12.023. Epub 2012 Jan 14.
Abstract
Contactin-2 was recently identified as an autoantigen targeted by T-cells and autoantibodies in multiple sclerosis (MS). Here we analyzed the frequency of antibodies to contactin-2 (contactin-2-ab) by a cell-based assay in the serum from 105 MS patients and at least 5 years of follow-up (19 clinically isolated syndromes, 51 relapsing-remitting, 20 secondary-progressive, and 15 primary-progressive). Contactin-2-ab were detected in 4 (7.8%) relapsing-remitting patients. Clinical and magnetic resonance imaging characteristics were not significantly different from the rest of relapsing-remitting patients. In conclusion, contactin-2-ab are identified in a minority of MS patients but their presence is not associated with a particular clinical-radiological profile.
摘要
接触蛋白-2 最近被鉴定为多发性硬化症 (MS) 中 T 细胞和自身抗体靶向的自身抗原。在这里，我们通过细胞测定法分析了来自 105 例 MS 患者和至少 5 年随访（19 例临床孤立综合征、51 例复发缓解型、20 例继发进展型和 15 例原发进展型）的血清中接触蛋白-2 (contactin-2-ab) 的抗体频率。在 4 例（7.8%）复发缓解型患者中检测到接触蛋白-2-ab。临床和磁共振成像特征与其他复发缓解型患者无显著差异。总之，接触蛋白-2-ab 在少数 MS 患者中被识别，但它们的存在与特定的临床-放射学特征无关。
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